I hope you enjoy reading this article as much as I did!
Eger EI 2nd. After you, please: the second Annual John W. Severinghaus Lecture on Translational Science. Anesthesiology. 2010;112(4):786-93.
He describes the challenges of his very first day delivering anesthesia, the origins of the concentration effect, the increase in CO2 in an apneic patient, how MAC came to be, expansion of the bowel from nitrous, why IQ goes up after general anesthesia (learning effect), and how the rate of increase of alvelaor gas concentration is faster in rats than in whales because ventilation and perfusion per kg is greater in the smaller animal.
